A new flavonoid for which the structure (2S) -5,8,4c-trihydroxy-6,7-vinylenedioxyflavanone was established and the known compounds stigmasterol, stigmasterol E-D-glucopyranoside, caffeic acid ethyl ester, and 3,4-methylenedioxycinnamic acid were isolated from Helichrysum arenarium.Keywords: Helichrysum arenarium, triterpenoids, phenylcarboxylic acid derivatives, flavonoids, PMR and 13 C NMR spectra.Helichrysum arenarium L. or everlasting is a perennial medicinal plant that is included in the pharmacopoeias of several European countries and has a long history of use in folk and practical medicine for treating various diseases [1, 2]. Recent research found strong antibacterial and anti-oxidant properties for various extracts of this plant [3][4][5][6].This species of everlasting has a very broad natural distribution because it grows in all regions of Europe, Asia Minor, Central Asia and in the Altai, Mongolia, and China [1].Populations of this plant indigenous to Europe are well studied with respect to their chemistry. It was found that the characteristic secondary metabolites of everlasting are isoprenoids (mono-, sesqui-, di-, and triterpenoids) and phenolic compounds (aromatic phenols and acids, coumarins, phthalides, flavonoids, etc.) [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20].It is well known that the qualitative and quantitative compositions of plant secondary metabolites can change depending on the habitat and vegetation period. Studies of the chemistry of the H. arenarium population indigenous to China were begun because of this and due to its broad use in traditional Chinese medicine [21][22][23].In continuation of the study of the chemical composition of everlasting indigenous to Xinjiang Autonomous Province of the PRC, the known compounds E-sitosterol (1), stigmasterol (2), E-sitosterol E-D-glucopyranoside (3), stigmasterol E-D-glucopyranoside (4), caffeic acid ethyl ester (5), 3,4-methylenedioxycinnamic acid (6), 3,5-dihydroxy-6,7,8-trimethoxyflavonol (7), and the new flavanone 8 were isolated by separation of the total EtOAc extract obtained by work up of the alcohol extract. Flavanone 8 is a yellow crystalline compound with formula C 17 H 12 O 7 , mp 224-225°C, [D] D -77.5°. The IR spectrum of 8 shows absorption bands characteristic of hydroxyls (3298 cm -1 ), carbonyl (1630), and an aromatic ring (1602 and 1498).