A new structure for an adenine-selective host molecule, featuring the pertinent link of five-six-five-membered heteroaromatic rings and two carbamoyl NH sites, was developed. This structure provides a correctly oriented array of complementary hydrogen bonding sites for the adenine nucleobase, which exploits both Watson-Crick and Hoogsteen-type interactions. The complexation with adenine nucleobases by multiple hydrogen bonding was supported by (1)H NMR spectroscopy. This type of host displayed high selectivity in complexation, with an accompanying fluorescent response to lipophilized adenosine in CHCl(3). Furthermore, a remarkably selective potentiometric response was attained for adenosine 5'-monophosphate over 5'-GMP, 5'-CMP, and 5'-UMP by using an ion-selective electrode with a PVC-supported solvent polymeric membrane. This indicates recognition of water-soluble nucleotide guests through the membrane-water interface. These findings are expected to form a reliable basis for the development of artificial sensing systems for mononucleotides in biological systems.

In this CD case complicated by subcutaneous aseptic neutrophilic abscesses, GMA appeared to be effective. Our impression is that when biopsy reveals neutrophil infiltrate is a major feature of the lesions, GMA should be considered. As GMA appears to have no safety concerns, a frequent GMA protocol, like daily followed by 2 to 3 times/week should be preferred over the routine weekly GMA.

No abstract

Neoadjuvant chemotherapy (NAC) is one of the main therapies for patients with local advanced breast cancer. CT and MRI have been used in combination with pathological examination in order to evaluate the efficacy of NAC. We present a case that showed discrepancies between the pathological findings and those of imaging analysis after NAC. We administered NAC to a patient with stage IIIB locally-advanced breast cancer. NAC showed remarkable drug efficacy. Clinical tumor response evaluated by CT and MRI showed a residual tumor. However, the pathological tumor response following NAC was grade 2b according to criteria of the Japanese Breast Cancer Society. Inaccurate determination of a residual tumor by MRI (a residual tumor diagnosed by MRI but a pathological complete response diagnosed by pathological examination) can occur occasionally.