The relationships between the morphologies and the permeability characteristics as dialysis membrane of polyether‐segmented nylon 610 (PE‐Ny610) have been investigated. PE‐Ny610 used are poly(propylene oxide) (PPO)‐segmented nylon 610 containing 25 wt % PPO (PPO‐Ny610) and poly(ethylene oxide) (PEO)‐segmented nylon 610 containing 15 wt % PEO (PEO‐Ny610). The morphologies in the cross section of the membranes exhibit the cellular porous structures due to liquid‐liquid phase separation. On the other hand, the structures of the surfaces are mainly composed of the crystalline spherulite due to liquid‐solid phase separation. These morphologies are little affected by the composition ratio of the coagulant, calcium chloride/methanol/water mixture. PEO‐Ny610 membranes have shown superior membrane performances to the PPO‐Ny610 membrane. The effect of PEO content in PEO‐Ny610 on the adhesion of platelet onto the PEO‐Ny610 film surface was investigated and it is concluded that PEO‐Ny610 having > 10 wt % PEO shows a good nonthrombogenicity equal to PPO‐Ny610. © 1997 John Wiley & Sons, Inc. J Appl Polym Sci 65:1713–1721, 1997

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ABSTRACT:The biocompatibility of poly(propylene oxide)-segmented nylon610 (PPONy610), poly(ethylene oxide)-segmented nylon610 (PEO-Ny610), poly(ethylene oxide)-segmented nylonM10 (PEO-NyM10), and poly(ethylene oxide)-segmented nylon69/M10 (PEO-Ny69/M10) hollow fibers were investigated in terms of the transient leukopenia by the extracorporeal circulation in a rabbit. PPO-Ny610 and PEO-Ny610 hollow fibers showed that the minimum leukocyte counts during the circulations were ú 80% against the initial count of leukocyte. These results indicate that these polymers have good blood compatibility. In PEO-NyM10 and PEO-Ny69/M10, the remarkable decreases of the leukocyte count were observed and the minimum counts were in the range of 45-50%. From the evaluation results of homo nylons (Ny610 and NyM10) hollow fibers, the low blood compatibilities observed in PEO-NyM10 and PEO-Ny69/ M10 are not attributed to the chemical structure of the nylon blocks.

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