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The current data show that propofol, mixed with clinical reagents (propofol MCT/LCT), resulted in the down-regulation of high oxidative stress due to scavenging hydroxyl radical, as demonstrated by in vitro or in vivo electron spin resonance analysis. These results led to reduced levels of hydroxyl radical, formed by brain injury such as stroke, and may therefore provide advantages for neuroprotection during anesthesia for craniotomy, e.g., in cases of brain disease.

In this work, we examined the antioxidant role of mucin, a typical sialic acid containing high-molecular weight glycoprotein. The function of mucin as a hydroxyl radical ( Å OH) scavenger was characterized using bovine submaxillary gland mucin (BSM). Non-treated BSM effectively protected DNA from the attack of Å OH; however, desialylated BSM lost this potential. Moreover, we estimated the scavenging effects of BSM against Å OH generated by UV irradiation of hydrogen peroxide using ESR analysis. Our results indicate that BSM has Å OH scavenging ability the and sialic acid in mucin is an essential moiety to scavenge Å OH.

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