Five groups of 20 Wister pure strain rats were fed on the same caries inducing diet 6PMV and excepting one control group, four groups were given drinks of the same fluoride ion strength of 10ppm prepared from NaF solution and tea infusion diluted with 10ppm NaF solution. After 30 days tea drinking resulted in more effective caries reduction than the NaF solution, and the reduction was in inverse proportion to the dilution of the tea infusion, suggesting that it contains many biologically active substances and possesses physicochemical properties for caries prevention. A clinical test of the effectiveness of tea drinking against dental caries in school children at Sumon resulted in favorable reduction of pit and fissure lesions as well as of lesions on the proximal surfaces of the teeth1). The water fluoridation technic had slight effect on pits and fissures according to previous reports2,8), which described the main fluoride action on the gingival and proximal surfaces of the teeth. The results of tea drinking, therefore, need to be confirmed experimentally. Tea naturally contains many biologically active non-fluoride substances4) which may work in caries potentiating or depotentiating and/or intervene in fluoride action. The present paper present evidence that the non-fluoride substances in tea have a caries preventive effect in rats. Methods To minimize the differences in tea components among different brands, five samples of 200

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Abstract:The cell surface substance prepared from Streptococcus mutans NCTC 10449was used as immunogen, and its protective effect against dental caries was investigated in hamsters.