Our objective was to assess the role of laparoscopic removal of ovarian endometriomas and ablation of peritoneal endometriosis on the outcome of intracytoplasmic sperm injection (ICSI) - Embryo Transfer cycles by comparing with the results of patients with untreated endometriomas and tubal factor without underlying endometriosis confirmed by laparoscopy. For this purpose, between 2002 and 2015, outcomes of 257 ICSI cycles of 150 patients, including 91 cycles of 48 patients in minimal endometriosis, 57 cycles of 25 patients in endometrioma removal, 65 cycles of 53 patients in non-operated endometrioma, and 44 cycles of 24 patients in tubal factor groups were retrospectively analyzed. Basal ovarian reserve was significantly lower, mean starting and total gonadotropin consumption was significantly higher, and mean serum E2 on the day of hCG injection, number of dominant follicles, number of retrieved total, and MII oocytes were all significantly lower in the endometrioma cystectomy group. Fertilization and embryo cleavage rates were also significantly the lowest in the endometrioma cystectomy group, whereas clinical pregnancy and live birth rates were comparable among all groups. The number of transferred embryos and duration of infertility were the most significant predictors of clinical pregnancy and live birth. Basal antral follicle count was also significant in predicting live birth.

Aim The study aimed to determine the frequency of possible missed diagnosis of gestational trophoblastic disease in nonviable pregnancies and to evaluate the importance of histopathological examination. Methods In this retrospective study, the results of the histopathological assessment of patients undergoing uterine surgery with a diagnosis of nonviable pregnancy were analyzed before 14 weeks of gestation. Nonviable pregnancy was defined as anembryonic pregnancy and intrauterine exitus (IU‐ex) based on ultrasound findings. The frequency and sonographic characteristics of molar pregnancy in nonviable pregnancy were analyzed. Results Molar pregnancy was detected in 24 (1.62%) of 1481 patients diagnosed with nonviable pregnancy on ultrasound. One thousand one hundred and twenty‐one of the cases were IU‐ex (75.69%) and the remaining were anembryonic pregnancy (24.31%). The mean crown‐rump length of pregnancies in the IU‐ex group was 16.7 mm and the mean gestational age was 8 weeks. The average gestational sac diameter was found to be 26 mm in anembryonic pregnancy patients. The hydatidiform mole ratio was significantly higher in anembryonic pregnancy patients (3.06%) than in IU‐ex patients (1.16%) (p = 0.013). Conclusions The appearance of early molar pregnancy on ultrasound evaluation may mimic anembryonic pregnancies. Therefore, histopathological examination of anembryonic pregnancies may be useful in early diagnosis and for the treatment of gestational trophoblastic neoplasia.

Background/aim: To investigate the optimal protocol for frozen-thawed embryo transfer (FET) cycles in patients who previously had a cycle cancellation due to uterine peristalsis (UP) Materials and Methods: Thirty-four patients with previous embryo transfer (ET) cancellation due to UP during artificial cycle (AC) were included retrospectively. In the proceeding cycle, endometrium was prepared with AC (n: 23) in AC-FET group or with stimulated cycle that contains letrozole (L) (n: 11) in L-FET group. Intravenous bolus dose of 6.75 mg atosiban (Tractocile; Ferring Pharmaceuticals, Switzerland) injection was performed to all patients of AC-FET group due to UP ≥ 4/min on the planned ET day of proceeding cycle. Atosiban was not used in L-FET group. Primary outcome was live birth rate (LBR) per ET. Secondary outcomes were clinical pregnancy rate (CPR) per ET, implantation rate (IR), cycle cancellation rate.Results: The baseline characteristics as age, body mass index, antral follicle count, duration of infertility and the number of prior in vitro fertilization attempts of each group were similar.The IR, CPR per ET, LBR per ET, CPR per cycle and LBR per cycle were significantly higher; cycle cancellation rates were significantly lower in L-FET group as compared to the AC-FET group.2 Conclusion: Endometrial preparation with letrozole significantly improves CPR and LBR in FET cycles of patients with previous cycle cancellations due to UP.

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To evaluate the effects of coronavirus disease-2019 (COVID-19) infection on clinical and laboratory features; maternal and fetal outcomes. Material and Methods: In this retrospective study, the patients diagnosed with COVID-19 by positive severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) reverse transcription polymerase chain reaction (RT-PCR) and delivered at Koru Hospital (Ankara, Turkey) between March 2020 and February 2021 were included. We obtained demographic, clinical, laboratory features, obstetric and delivery history, maternal and perinatal outcomes from medical records. Results: Twelve pregnant patients were included in the study. The mean age was 32 years (range 28-43 years) and the mean gestational age at diagnosis of COVID-19 was 34 weeks (range 22 to 39 weeks 6 days), the mean gestational age at delivery was 38 weeks 4 days (range 35 to 40 weeks). All deliveries were as cesarean section. At first admission with suspicion of COVID-19, seven (58%) patients had fever, five (41%) patients had cough, two (16%) patients had dyspnea, two (16%) patients had anosmia and loss of taste, one (8.3%) patient had sore throat. None of the pregnant patients were taken to the intensive care unit before or after delivery. One neonate was tested for SARS-CoV-2 RT-PCR and the result was negative. Two neonates were admitted to neonatal intensive care unit due to preterm delivery of a twin pregnancy. Conclusion: COVID-19 infection has similar clinical characteristics in pregnant patients as in non-pregnants reported in the literature. The maternal, fetal and neonatal outcomes were good and vertical transmission seems unlikely.