Introduction: Chuanxiong is a herb used in traditional Chinese medicine for the Treatment of viral encephalitis. In animal studies it has shown to inhibit the synthesis and activity of Thromboxane (TXA2) and abate the imbalance between Thromboxane (TXA2) and Prostacyclin (PGI2). As a result, cerebral edema, ischemia and hypoxia could be improved. The aim of this study is to evaluate its effect in the treatment of viral encephalitis in children. Methodology: Ninety-nine patients with viral encephalitis were randomly divided into two groups. Ligustrazini Hydrochlorioi (LH) consisting of 51 cases (males 30, females 21; age 5 years and nine month±8 years and 2month) was given LH 4mg/kg per day in 100-300mls of 10% glucose and infused intravenously over a three to four hour period, for 7 days as a course of treatment. A control groups of 48 cases(males 31, females 17; age 5 years and three month±4 years and three month) received the conventional treatment of Vitamin C(2.0-3.0g), Coenzyme A(100u) and Adenosine Triphosphate(ATP)(40mg) in 100-300 mls of 10% glucose infused intravenously daily for 7 days. Results: The total response rate in the LH group and the control group were 94.12% and 68.75% respectively (u=3.271 p<0.05). The average time to improvement was 4.29±1.41 days and 7.31±2.66 days respectively. No adverse effect was observed in both groups. Conclusion: We conclude that LH is an effective, safe and well tolerated treatment for children encephalitis.

Background: Neonatal acute hematogenous osteomyelitis is very rare in clinical research. Early diagnosis and treatment to reduce the sequelae is very important. The purpose is to introduce a rare and special case to medical workers, so that readers know how to diagnose and treat such special cases. Methods: Through the clinical manifestations, imaging studies and the results in blood culture. Results: There were no adverse sequelae after effective antibiotics, which were discharged. Conclusion: There is great importance in early diagnosis and treatment of neonatal osteomyelitis.

Objective: Retrospective clinical analysis of adverse drug reactions in children. Methods: Clinical data analysis was performed on 844 cases of hospitalized children reported for adverse drug reactions. Results: Children under 3 y of age were more prone to the adverse drug reactions; adverse reactions were mainly caused by antibiotics and traditional Chinese medicine; intravenous rout was the most common mode of administration of drug causing adverse reaction; adverse drug reaction was mostly observed within 1 h of drug administration; most common clinical manifestation of adverse drug reactions was the skin damage. Conclusions: More attention should be paid towards rational use of drugs, to avoid multiple drug use as far as possible, and to focus on prevention of adverse drug reactions, timely detection if happened and immediate treatment. Establishment of drug reaction reporting system will definitely help the physicians across the globe to better understand the phenomenon.

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Aminophylline is important drug for the treatment of bronchial asthma. Aminophylline by Intravenous injection is quick effect, good curative effect, but the safety margin is small, the body eliminate rate of individual difference is bigger, if use undeserved, often easy to cause serious side effects, and even death. Analysis for 110 cases of children with aminophylline poisoning were 1 year old children poisoning cases in the highest, accounted for 55.5%, in 110 cases main disease is bronchiolitis (asthmatic suffocating pneumonia), the most common symptoms is nausea and vomiting, accounted for 72%, maximum dose of 1500 mg . the treatment is gastric lavage, intravenous fluids, medicine for cardiac failure, diuresis and blood perfusion and hemo-dialysis etc.