Background: Non-steroidal anti-inflammatory drugs (NSAIDs) hypersensitivity is one of the leading cause of adverse reactions and a matter of concern in susceptible patients, with NSAIDs induced urticaria/angioedema (NIUA) being the commonest phenotype. Positive associations between the human leukocyte antigen (HLA) and NSAIDs hypersensitivity have been observed in different populations.

Introduction: Beta-lactam allergy can be currently diagnosed based on positive skin testing, serum-specific IgE, or provocation challenge. In adults, sensitivity and specificity of skin testing and serum-specific IgE in the context of assessing distant reactions are poor. Paediatric data in this regard are missing.

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