Lactic acid bacteria have a high potency to combat infections in the body. The range of lactic acid bacteria isolated from aquaculture in Uzbekistan has been described in this article. We found that Lactobacillus delbrueckii, L. plantarum, L. sakei, L. brevis, Lactococcus lactis, Pediococcus acidilactici, P. pentosaceus, Enterococcus faecium, E. hirae, E. mundii, E.faecalis, Leuconostoc citreum, and Weisella sibaria strains are represented in hydrobionts. Among them isolates Lactobacillus delbrueckii R1, Lactobacillus plantarum Kr5, Pediococcus acidilactici B, Enterococcus faecium R2, Lactobacillus plantarum R3, Pediococcus pentosaceus R1 showed high antagonistic activity against aquaculture pathogens. Four strains: Lactobacillus plantarum Kr5, Pediococcus acidilactici B, Enterococcus faecium R2, and Pediococcus pentosaceus R1, meet all the criteria for probiotics and can be recommended as part of probiotic feed additives.

The study aimed to evaluate the hypoglycemic activity of lactic acid bacteria isolated from the medicinal plants possessing antioxidant and hypoglycemic properties growing in Uzbekistan and analyze their prоbiotic properties. Four plant isolates of lactic acid bacteria (LAB) and three commercial strains were used in the study. Alimentary hyperglycemia was induced in white outbred rats, and glucose level was measured before and after treatment with lactic acid bacteria according to the experiment scheme using an intraperitoneal glucose tolerance test. The investigation was shown that strains of Lactobacillus kunkeei 1, L. рlantarum TK1, L. рlantarum KA3, Enterococcus faecium effectively reduce postprandial hyperglycemia in rats. Moreover, evaluation of their probiotic properties: sensitivity to antibiotics, simulated gastric juice, simulated juice of small intestine, bile, and elevated concentration of sodium chloride, demonstrated that the strains Enterococcus faecium 1, Lactobacillus kunkeei 1, L. рlantarum TK1, L. рlantarum KA3 meet the criteria for probiotics. These strains could be considered promising candidates for the preparation of probiotic preparations intended not only to correct gut microbiota but also to maintain normal blood glucose levels.