In this study, epidemiological survey on nicotine induced oral cancer on its various prospective is carried out. Comparative studies of various risk factors that develop oral cancer in patients like age, sex, location etc. are studied. In the present study, three different factors were used to study the therapeutic effect of by measuring the outcomes like ADR, DI, Clinical efficacy produced by the drugs. Study found that ADR and symptomatic changes were less in case of combination chemotherapy compared to mono chemotherapy.

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