Currently, there are about 195 nations in the world, with a population of 7.8 billion. This much higher the population directly influences higher food demand. Due to this interlink massive amount of food waste has been collected from the meat industries; especially poultry plays a major role by discharging feathers into dumps. There are about 8.5 billion tons of feathers that are wasted every year which lead to high global environmental risk and cause different human disease. This high risk is due to typical structure of feather. They have a matrix protein called keratin that makes degradation more tedious under normal condition; they are insoluble in nature with high rigidity due to the disulfide bridges. By extraction of keratin from these waste feathers are used for multipurpose such as cosmetics, biomedical, textile use, bio-fertilizers etc. In addition, as per trend by utilizing nature’s gift the microorganisms we can breakdown these matrix proteins easily. By this environmental friendly technique our works gets easier and are also cost effective. By consumption of keratin as substrate some microorganisms produce an extracellular enzyme called keratinase which has the ability to cleave the protein. The produced keratinase is a wealth out of waste which has wide biochemical properties and also used for waste water treatments. On whole the feather considers as waste is completely turned to verity of useful products ubiquitous like biodiesel, biofertilizer, biodegradable plastics, biofilms, skin, hair and other biomedical treatments.