Inclusion complexes of nicardipine HCl (NIC) with β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) were prepared using different methods: coevaporation, kneading and co-precipitation. Inclusion complexation in aqueous solution and in solid state was studied by the solubility method, Fourier transform-infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC) and X-ray diffractometry (XRD). The solubility of (NIC) increased as a function of cyclodextrin concentration, showing Bs and AL type diagrams for (β-CD) and (HP-β-CD), respectively. The dissolution rate of (NIC) / cyclodextrin complexes were investigated and compared with those of the physical mixtures and pure drug. The dissolution efficiency of (NIC) increased by complexation with cyclodextrins to 2.8-2.9 fold than (NIC) alone. Oral bioavailability in rabbits increased to~6 fold by complexation with (β-CD).

In terms of the importance of enhancing concrete coastal structures exposed to chlorides, this study was initiated with the objective of increasing their lifespan. Two measures were proposed (i.e. to increase the thickness of the concrete cover oradd Carbon Fiber Reinforced Polymer (CFRB) sheets).27 R.C. specimens were investigated experimentally. The specimens were exposed to variable sodium chlorideratios by weight "salt cement ratio"(s/c) (i.e. 3:100 "3%", 3:50 "6%" and 1:10 "10%"). The specimens were prepared, cured, dried and tested. The Zagazig Structural Laboratory was set. Measuring devices were fixed and measurements were undertaken. Also, photos were captured and observations were documented. The strains, cracking load and cracking pattern were determined.The undertaken measurements, the shot photos and documented observations were analyzed; graphs relating the different parameters were plotted and were presented. It was found that these enhancement measures improved the behavior of the concrete specimens subjected to Chlorides which would most probably extend the lifespan of concrete coastal structures. U ‫ﺍﻟﻌﺮﺑﻰ:‬ ‫ﺍﻟﻤﻠﺨﺺ‬ ‫ﻳﺘﻌﻠﻖ‬ ‫ﻓﻴﻤﺎ‬ ‫ﺑﺄﻫﻤﻴﺔ‬ ‫ﺍﻟﺘﻰ‬ ‫ﺍﻟﺨﺮﺳﺎﻧﻴﺔ‬ ‫ﺍﻟﺴﺎﺣﻠﻴﺔ‬ ‫ﺍﻟﻤﻨﺸﺄﺕ‬ ‫ﻣﺸﺎﻛﻞ‬ ‫ﺍﻏﻠﺐ‬ ‫ﻋﻦ‬ ‫ﺗﺪﻫﻮﺭﻫﺎﻳﻨﺘﺞ‬ ‫ﺻﺪﺃ‬ ‫ﺻﻠﺐ‬ ‫ﺍﻟﺘﺴﻠﻴﺢ‬ ‫ﻫﺬﺍ‬ ‫ﻓﻰ‬ ‫ﺍﻟﺒﺪء‬ ‫ﺗﻢ‬ ‫ﺍﺟﺮﺍء‬ ‫ﺍﻟﻰ‬ ‫ﻳﻬﺪﻑ‬ ‫ﺍﻟﺬﻯ‬ ‫ﺍﻟﺒﺤﺚ‬ ‫ﺩﺭﺍﺳﺔ‬ ‫ﻋﻦ‬ ‫ﻣﻌﻤﻠﻴﺔ‬ ‫ﺻﺪﺃ‬ ‫ﺻﻠﺐ‬ ‫ﺍﻟﺘﺴﻠﻴﺢ‬ ‫ﺍﻣﻼﺡ‬ ‫ﻣﻦ‬ ‫ﻋﺎﻟﻴﺔ‬ ‫ﻧﺴﺐ‬ ‫ﺗﻮﺍﺟﺪ‬ ‫ﻋﻦ‬ ‫ﺍﻟﻨﺎﺗﺞ‬