Increased MDA levels are with closely associated with the severity and patients status of periodontal disease that has not been previously reported. The detection of salivary MDA level may provide additional advantages in elucidating the pathogenesis of periodontal disease.

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Purpose. To examine the effectiveness of using local nano-gel NBF Gingival Gel at the stage of primary periodontal therapy of patients with chronic catarrhal gingivitis and generalized periodontitis based on the use of clinical and biochemical research methods. Methods. Appreciate the effectiveness of local nano-gel NBF Gingival Gel with the objective of periodontal indices, monitoring of patients and biochemical studies content in the oral fluid (OF) of indices of free radical oxidation (MDA) and antioxidant defense (glutathione reductase). Results. Usage of nano-gel NBF Gingival Gel at the stages of primary periodontal therapy for 80 patients with chronic catarrhal gingivitis (CCG) and generalized periodontitis (GP) I, I–II degree demonstrated good clinical anti-inflammatory effect, which based on its pronounced antioxidant and antimicrobial mechanisms of action. NBF Gingival Gel is not irritating of periodontal tissues and the mucous membrane of the oral cavity, has good organoleptic qualities. Conclusions: In addition to basic treatment in primary periodontal therapy of patients with inflammatory periodontal disease should be to use local drugs with directed pathogenetic mechanism of action, which include nano-gel NBF Gingival Gel with antioxidant mechanism of action.

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Complex treatment of moderate and severe generalized periodontitis includes surgical phase of treatment in aim to provide regeneration and long-term disease remission. The obtained results confirm presence of osteoinductive properties in enamel matrix proteins, this data may be useful during surgical procedures on periodontal tissues.