ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

A New Synthesis of Substituted Fulvenes.-In the presence of a Pd catalyst fulvenes (III) are obtained from the vinyl iodides (I) and the acetylenes (II). Addition of CuI directs the reaction to the formation of enynes (30 examples). -(LEE, G. C. M.; TOBIAS, B.; HOLMES, J. M.; HARCOURT, D. A.; GARST, M. E.; J. Am. Chem. Soc. 112 (1990) 25, 9330-9336; Dep. Chem. Sci., Allergan Inc., Irvine, CA 92715, USA; EN)

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

A General Approach to 5-Substituted 3-Furaldehydes.-3-Furaldehyde (I) is protected in situ with lithium morpholide and further dilithiated with sec-BuLi to give the intermediate (II). This reacts with electrophiles such as (III) or (VI) to form mainly or exclusively 5-substituted 3-furaldehydes. Consecutive reaction of (IVc) with lithio N,N,N'-trimethylethylenediamine and sec-BuLi yields the complex (VIII) which is treated with methyl iodide to form the 2,5-disubstituted 3-furaldehyde (IX). Analogously, the 4-substituted 3-furaldehydes (XI) are regioselectively converted to the methylation products (XI) or (XII) depending on the lithium amide employed. -(LEE, G. C. M.; HOLMES, J. M.; HARCOURT, D. A.; GARST, M. E.; J. Org. Chem. 57 (1992) 11, 3126-3131; Dep. Chem. Sci.,