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The dependence of the partial specific volume of various proteins on their concentration in solution was studied. The following proteins were investigated: lysozyme, pepsin and various hemocyanins as well as their fragments (molecular weights between 14000 and 4500000). The concentration of the solutions of the proteins was varied in a wide range (4 mg/cm3 to 220 mg/cm3). In no case a dependence of the partial specific volume on the concentration could be observed. For pepsin and lysozyme the dependence of the partial specific volume on the temperature of the solution was studied, too. With both proteins investigated a nearly linear increase of the partial specific volume with the temperature [(39 ± 1).10−5 cm3 g−1 K−1] was observed in the temperature range of 4°C to 25°C.

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