Adaptive response of fibroblasts from skin biopsy specimens from patients with gout has been studied; these cells are characterized as reparation-detective during exposure to mutagens Nmethyl-N'-nitro-N-nitrosoguanidine and 4-nitroquinolin-N-oxide. Adaptive response formed during exposure to nitrosoguanidine. The data indicate that the formation of adaptive response does not depend on DNA reparation.
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