The article deals with a case of the clinical observation of a rare disease: generalized eruptive keratoacanthomas of Grzybowski. The disease pattern is characterized by the presence of small, generalized, itchy papules on the skin of the face, eyelids, trunk, extremities, genitals, and oral and laryngeal mucosae. The authors present a case of their own clinical observation of multiple eruptive keratoacanthomas of the Grzybowski type in a fifty-year-old patient seeking medical advice from a dermatologist. The duration of the disease was 2.5 years and its occurrence was preceded by repeated visits to countries with excessive insolation, which may be considered an etiological factor in the development of the disease. The diagnosis was verified by the disease pattern and pathomorphological studies on a biopsy of the affected skin.

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