: Bioadhesive films are considered as a novel drug delivery system which provides improved therapy and better patient compliance than conventional dosage forms. The type and concentration of polymer or the blend of polymers used are important factors influencing the properties of bioadhesive films and influencingthe product outcome and performance. But the modification of available polymers to synthesize polymers with improved properties is the current area of research. Furthermore, addressing the challenges in formulating bioadhesive films for transdermal delivery of a variety of different classes of drug molecules is the frontier for future research. With the advancement of synthetic chemistry and the development of newer technology like 3D printing, more and more studies are going on bioadhesive films that have opened up a bunch of opportunities in this field of research. This article reviews the current advancements in developingbio-adhesive films and provides basic principles that will be helpful to overcome the difficulties that are associated with the design of formulation.