Organic chemistry Z 0200 Synthetic Route to Ergot Alkaloids -[37 refs.]. -(MOLDVAI, I.; TEMESVARI-MAJOR, E.; INCZE, M.; DOERNYEI, G.; SZENTIRMAY, E.; SZANTAY*, C.; Helv. Chim. Acta 88 (2005) 6, 1344-1356; Chem. Res. Cent., Hung. Acad. Sci., H-1525 Budapest, Hung.; Eng.) -S. Adam 40-257

Synthesis, anti-GABA Activity and Preferred Conformation of Bicuculline and Norbicuculline Enantiomers. -The title compounds (VII) and (IX) are prepared using the Bischler-Napieralski cyclization. (+)-Bicuculline (IX) is 70 times more potent than its enantiomer as an inhibitor of GABAA receptor binding and 900 times more potent than (+)-norbicuculline (VII) at pH 5. -(KARDOS, J.; BLANDL, T.; LUYEN, N. D.; DOERNYEI, G.; GACS-BAITZ, E.; SIMONYI, M.; CASH, D. J.; BLASKO, G.; SZANTAY, CS.; Eur.

Aus den Isochinolinen (I) werden mit dem Oxaziridin (II) die Cyclohexylidenhydrazine (III) gebildet, die mit HCl zu den Hydrazinen (IV) gespalten werden, welche auch als Hydrazone (VI) charakterisiert werden können.

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Pyridine derivativesPyridine derivatives R 0380 Synthesis of Some New 4-Substituted N-Benzyl-piperidines. -A new approach to the important intermediate N-benzyl-piperidine-4-ethanol (VII) via Knoevenagel condensation of N-benzyl-4-piperidone (I) with malodinitrile (II) is outlined. The overall yield starting from (I) is about 55%; the advantages of the new process are simplicity, inexpensiveness, and capability for scaling up. -(DOERNYEI*, G.; INCZE, M.; MOLDVAI, I.; SZANTAY, C.; Synth. Commun. 33 (2003) 13, 2329-2338; Chem. Res. Cent., Hung. Acad. Sci., H-1025 Budapest, Hung.; Eng.) -H. Haber 44-125