Diabetic foot ulcers (DFUs) are serious complication of diabetes. Offloading devices treat DFUs by distributing force and reducing pressure across the wound. Adhering to appropriate use of offloading devices is a key strategy to promote DFU healing. However, some people who are highly adherent to offloading device use still do not heal. Factors such as wound and diabetes characteristics, motor function, and patient reported outcomes may help distinguish healed and non-healed patients. In our study, we analyzed data from 23 participants. Factors were graded on a scale from 0 to 10 based on thresholds found in the literature (Figure 1). We then calculated the effect size of each factor using Cohen's d between the healed and non-healed groups (Figure 2). Our results showed that cognition had the largest effect size, with a value of d = 1.63. Disclosure G.Cay: None. G.Finco: None. J.A.Garcia: None. E.Salazar: None. D.Vigano: Board Member; Sensoria Health Inc. M.Macagno: Board Member; Sensoria Health Inc. D.G.Armstrong: Research Support; Medaxis LLC. B.Najafi: Consultant; BioSensics LLC, Mölnlycke Health US, LLC, Research Support; AVAZZIA, EO2 Concept, LifeNet, Neurometrix, Medline, SmarTek21. Funding National Institute of Diabetes and Digestive and Kidney Diseases (R01DK124789)