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The course of experimental amyloidosis in mice by means of caseinate injection as first described by Kuczynski ( 5 ) in 1922 may be accelerated in various ways. Teilum (12) showed 1952, that female mice of C3H-strain treated with subcutaneous injections of 0.5 ml 2 per cent casein in 0.25 per cent NaOH did not show any signs of amyloidosis, while mice, which received 0.3 mg of cortisone together with the caseinate injections, had a pronounced amyloidosis. Another important point found was, that pretreatment with caseinate for six weeks followed by injections of 0.3 mg cortisone for four days resulted in a rapid development of amyloidosis, which was substantiated by biopsy of the spleen. ACTH had a similar effect on the caseinate-induced amyloidosis.

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