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Previous investigations have shown that when cells of the Shay chloro-leukemia of the rat are inoculated into animals of different age subcutaneously, intraperitoneally or intravenously, various forms of chloromatous and leukemic processes develop. In the present studies, the porphyrin concentration and the myeloperoxydase activity of these various forms were studied by quantitative methods. It was found that the porphyrin concentration and the myeloperoxydase activity of the tissues show an inverse relationship; i.e., in tissues with high myeloperoxydase activity, porphyrin concentration was low and in those with low myeloperoxydase activity, the porphyrin concentration was high. Possible causes of the reverse relationship of the two components of the chloroleukemic tissues are discussed.

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