The proposita of a Canadian family and 2 of her sibs have the rare Leach phenotype and provide the first
evidence that the Leach phenotype is an inherited condition. Their red cells are Ge: -2, -3 and fail to react, by the
antiglobulin test, with the monoclonal antibodies GERO, BRIC 4 and BRIC 10. The minor sialoglycoproteins β, β(1)
and γ are apparently absent from their red cell membranes. A proportion of their red cells are elliptocytes indicating
that β and/or β(1) and/or γ have a function in maintaining normal red cell shape.
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