In the crystal structure of the title compound, 2C5H5N4O+·SO4 2−, N—H⋯O hydrogen bonds assemble the mol­ecules into a two-dimensional network structure parallel to the cb plane. The S atom of the sulfate ion lies on a special position on a twofold axis.

In the crystal structure of the title compound [systematic name: 1-ethyl-6-fluoro-4-oxo-7-(piperazin-4-ium-1-yl)-1,4-dihydro­quinoline-3-carboxyl­ate sesquihydrate], C16H18FN3O3·1.42H2O, N—H⋯O and O—H⋯O hydrogen bonds assemble the mol­ecules in a two-dimensional layered corrugated sheet structure parallel to the b axis. The water mol­ecules are disordered [occupancies 0.741 (11) and 0.259 (11)].

Interaction study of paracetamol with saturated and unsaturated fatty acids, namely, capric and oleic acid have been performed by using serial dilution method, release behavior, FT-IR, and DSC study. Preliminary investigations by release studies indicated the possibility of interaction between paracetamol and fatty acids. UV-studies failed to detect any interaction between paracetamol and fatty acids. The possibility of hydrogen bonding between amino group of paracetamol and carbonyl group of fatty acids was revealed by FT-IR study. Polymorphic transition of paracetamol in the binary sample of paracetamol-capric acid was identified by DSC studies. However, no such possibility was detected in paracetamol-oleic acid mixture.

No abstract

Modification of surface morphology without significantly altering the polymorphic state can be utilized for improving physical stability of TMP suspensions. However, the pharmacokinetic profile remains unaltered.