Conclusions: LAAC is safe and effective in patients with NVAF and OAC contraindication. At 32 months, the thrombotic events rate reduced by 73% to 76% from CHADS 2 or CHA 2 DS 2-VASC predictions. Device-related thrombus or leaks may be associated with an increased incidence of stroke. Gastrointestinal bleeds are highly predictive of new bleeds during the first year.
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