The qfect of and the combined action of ephedrine hydrochloride and 20-rnethylcholanthrene (Experiment No. 2 ) on the mucosa of the glandular stomach was studied in 2.5 rats. The application of the two chemicals was carried out by means of specially constructed containers which were inserted into the wall of the glandular stomach. Polyethylene-encased wicks led from the container, touching the gastric niucosa with their tips. The chemicals were slowly pumped by stomach acfion through the wicks 011 to the mucosa. The experiments lasted .from 14 to 20 months. In Experiment No. I (32 rats) stomach tumours developed in 5 rats, in Experiment No. 2 (21 rats), in 7 rats. Most of the tumours were adtnocarcinomas. The tumours were large and invaded the serosa of the stomach. In Experiment No. 2 jive tumours out of seven showed metastasis in various organs and tissues of the abdomen.

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