The structure of membrane-active antibiotic cyclodecapeptide gramicidin S in the crystals of its complex with urea, C60H92N12010.0.5[(NH2)2CO ].7.94H20 , has been investigated with three-dimensional X-ray data by the automatic sequential approximation method. The crystals are trigonal, space group P3121, a = 25.80(3), c--21.49(2)A, M r = 7968, calculated density = 1.088mg m -3, Z = 1. Conventional R factor: R1 = 0.0943, wR2 = 0.2478
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