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A meningioma demonstrating unusual anatomical and clinical manifestations is described. This intracranial tumor originated in the petrous region and extended into the neck, the patient remaining neurologically asymptomatic for nearly 2 years. The radiological features of this tumor as well as a review of the pertinent literature are presented.

AND SummaryTwo patients are described who had acute severe idiopathic thrombocytopenic purpura (ITP) presenting in late pregnancy. In both there was little or no response to corticosteroid therapy and elective Caesarean section and splenectomy were performed. The babies had marked thrombocytopenia which disappeared spontaneously. It is suggested that in acute ITP Caesarean section is indicated on paediatric grounds and poses no untoward maternal risk when combined with splenectorny and platelet transfusion.

IL-6 for 48 hours. CD40, CD80, CD83, CD86, DC-SIGN and HLA-DR expression was evaluated before and after the HIV-1-stimulation and IL-12 concentration were measured by ELISA. HIV-1-specific lymphoproliferation was analyzed by flow cytometry in 6-day cocultures of MDDC and lymphocytes. Nonparametric tests were employed (p<0,05).Results: The %mDC wasn't different among groups (medians: 1.9% for AP, 2.45% for VP and 1.95% for controls; Kruskal-Wallis test, p=0.071) and there was a difference of %pDC between patients and controls (medians: 0.3% for AP, 0.1% for VP and 0.3% for controls; Kruskal-Wallis test, p=0.038). VL inversely correlated with %pDC (Spearman's rho=-0.314; p=0.016) and mDC inversely correlated with %CD4 (Spearman's rho=-0.390; p=0.003).Before HIV stimulation, MDDC from VP had high level of CD83 expression than controls (p=0.011). After HIV stimulation, MDDC from all groups had higher HLA-DR, CD40, CD80, CD83 and CD86 and lower DC-SIGN expression. We didn't find a difference in IL-12 concentration among groups (medians: 2053.8pg/mL for AP, 2458.4pg/mL for VP and 1626.2pg/mL for controls; Kruskal-Wallis test, p=0.539). Higher HIV-specific proliferation was found in patients with AP in comparison to VP (medians: 12.4% for AP and 0.69% for VP; Mann-Whitney test, p=0.006).Conclusion: Therefore, in children under ART, viremia was associated with lower %pDC, altered MDDC phenotype and reduced HIV-specific lymphoproliferation.