The reproducibility study has therefore validated the epidemiologic study and in particular allowed to correct some misclassifications that could have lessened the analysis of the case-control study. In general, because of its characteristics (number of pathologists and variety of their origins, the large number of cases examined, blind examination of histologic slides), the conclusions of the study may show a certain degree of generalization, at least with regard to the countries represented. Routine histologic diagnoses of cutaneous carcinoma showed a high degree of reliability with reference to the assessment of malignancy and the distinction between basal and squamous cell carcinoma morphotypes.

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Se presenta un nuevo caso de trisomía 17-18 con cariotipo 47, XX, E+. Se trataba de un recién nacido, hembra, que falleció a las 96 horas de vida con un cuadro de cianosis generalizada. Se describen detenidamente las anomalías observadas entre las que destacan, además de los rasgos característicos del hábito externo, doble comunicación interventricular, ductus permeable, riñón en herradura microquístico, megauréter doble izquierdo y hernia diafragmática. Por último, se encarece la necesidad del estudio citogenético para establecer un diagnóstico de certeza del síndrome de Edwards.