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Increased serum creatine phosphokinase (C.P.K.) levels have been shown in acutely psychotic patients on admission to hospital (Meltzer, 1968). Little is known about C.P.K. activity in non-psychotic (e.g. neurotic) patients admitted under similar conditions. Psychotic patients have not been compared with non-psychotic patients over a period of time following admission. Examination of a single serum sample for C.P.K. activity in non-psychotic patients at the time of admission has shown no abnormality (Meltzer et al., 1969).