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2,3,4,5‐Tetrahydropyridine trimer product: 2,3,4,5‐ Tetrahydropyridine trimer intermediate: Isotripiperidein product: β‐ (m.p. 70–73°) tripiperidein product: α‐Tripiperidein

A series of alpha-cycloalkylphenylmethyl lactamimides and a series of furan- and thiophenealkyl lactamimides were prepared for biological evaluation as an extension of earlier finding of hypoglycemic activity in lactamimides. Compounds 7, 20, 23, 25, 29, and 32 produced pronounced hypoglycemia after oral administration to fasted, glucose-primed rats.

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