No abstract

Subcutaneous experiments with the albino rat demon¬ strated that the addition of 2.5 per cent, procain to the magnesium sulphate solution (50 per cent.) or to the magnesium sulphate solution with morphin increases the efficiency, definitely prolongs the effect, and allays irritation, without increasing toxicity. The synergism between magnesium sulphate and procain is definite because procain in itself produces no general analgesic action when injected subcutaneously in the albino rat. The addition of 2.5 per cent, procain increased the efficiency of the magnesium sulphate approximately 50 per cent. The combination of magnesium sulphate (50 per cent.) with procain (2.5 per cent.) may be a

Operation, and the ineffectiveness of roentgen irradia¬ tion on the remaining tissue emphasize the therapeutic importance of removing the entire gland at the time of the first operation. Ample confirmation for this con¬ clusion was obtained by our subsequent experience in some fifty cases of angina pectoris or congestive failure, in all of which the basal metabolic rate remained low after total ablation of the thyroid gland, and in practi¬ cally all of which the clinical improvement has been conspicuous.330 Brookline Avenue.

No abstract