Thrombohemorrhagic balance is maintained by complicated interactions between the coagulation and fibrinolytic system, platelets, and the vessel wall. Dr. Virchow provided approach for investigating and managing thrombotic disorders. He proposed stasis, vascular injury, and hypercoagulability as causes for thrombosis. In 1965, antithrombin deficiency was described. After two decades, protein C and protein S deficiencies, mutations of factor V Leiden, and factor II were described. If we distinguish patients at high risk and low risk of thrombosis, we can optimize therapeutic decisions. There is currently no evidence to say that laboratory abnormality should influence intensity of anticoagulation. In this article we reviewed the risk factors and need for thrombophilia screening in patients. Screening general population for thrombophilia is not justified or recommended at this time.

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Soma yoga is an important formulation in shwas rogadhikar in the Sidha yoga sangraha of Yadav ji Trikam Ji. At the time of present study not much research work was done on this formulation. Somlata is known for its anti-asthmatic properties. In the present study it is in a compound form with a common mercurial preparation Rasa Sindura, with an eye to understand its yogvaahi property. The preparation of Rasa Sindura forms the prototype for all the other Kupipakva Rasayanas (concept developed in relation to the procedure of Gandhaka jarana). Hinguloth Parad (mercury extracted from Cinnabar) was chosen for making the base for Rasa Sindura preparation. The involvement of two important alchemical procedures Kupipakva Nirmana and Hinguloth Parad extraction formed the reason for drug selection. The drug was subjected to modern analytical tools as XRD, FTIR, PSA and ICP analysis to satisfy the growing vigilance regarding the form of metal or mineral present and freedom from unwanted toxic heavy metal contaminants. It can be concluded from the study that Rasa sindura is chemically, the red sulfide of mercury with the presence of organic bonds.Trituration with water helps in uniform distribution of rasa sindura and helps in better absorption because of smaller particle size. It is suggested to use demineralised water for preparation of drugs; the possible source of the presence of cadmium in the study was water.

Asthma is a significant burden, not only in terms of health care costs but also, of lost productivity and reduced participation in the social and triturated into a fine powder. It is taken in a dose 5-10 Rattis with water or honey as vehicle in Shwas Roga or Asthma. Somlata is known for its anti asthmatic properties. In the present study it is in a compound form with a common mercurial preparation Rasa Sindura,