Keywords:Dimethyl phthalate, one-pot synthesis, green synthesis and water; 2H-indazolo[2,1-b]phthalazine-trione derivatives Water mediated one-pot, four-component synthesis of substituted 2H-indazolo[2,1-b]phthalazine-triones from dimethyl phthalate, hydrazine, dimedone and aromatic aldehydes have been reported in the presence of p-toluenesulfonic acid (PTSA) as catalyst at 100 °C for 1.5-2.0 h. This methodology offers several advantages such as good yields, short reaction time, simple procedure, mild condition and environmentally begins.
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A novel, efficient, and high-yielding one-pot three-component method was developed for the synthesis of 2-(1H-benzo[d]oxazole-2-yl)-Narylbenzamides by combining phthaldichloride with anilines & o-aminophenol in water without any external catalyst. The environmentally friendly procedure, easy operation and mild reaction conditions enable the tolerance of a wide scope of functionalities as well as high reaction efficiency.
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