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A young male had an assumed dentigerous cyst marsupialized and later a recurrent ameloblastoma resected. Eleven years later he was admitted with renal stones and hypercalcemia and metastases of the ameloblastoma in the left lung were discovered. Death occurred as a result'of spinal and hepatic spread of his tumor and thrombosis of the renal veins. Renal calcification was demonstrated. The possible causes of the hypercalcaemia which was not associated with a raised serum parathormone or affected by parathyroidectomy is discussed.Cancer 36:2277-2285, 1975. ROM TIME TO TIME, CASES ARE REPORTEDThe upper molars bit into the swelling and at this site F of ameloblastomas which have spread ei-the mucosa was inflamed. There was no limitation of ther to the lungs, or to the regional lymph nodes. opening. Such cases are uncommon and frequently the His general health was good, there was no past accounts contain of uncertainty. ~h~~ history of serious illness, and he was a non-smoker. Radiographs revealed a circumscribed bone cavity is reported because metastatic spread of the neo-which involved the right mandible from immediately plasm was accompanied by hypercalcaemia, the distal to the first molar back to the base of the coroproduction of renal calculi a n d metastatic calcifi-noid process and the neck of the condyle (~i~. 1~) cation; a circumstance which, a s far a s we are Only the crown of the third molar, together with aware, has not previously been recorded. about 2 mm of thin, cervical dentine was formed and the tooth was displaced down to the angle of the mandible. The periodontal membrane of was thickened on the distal aspect of the mesial root. Both Of the ramus exhibited quite marked expansion. The appearance was as a dentigerous cyst.At operation a considerable quantity of clear serous fluid was released and a piece of the cyst wall distal to removed, 9/ was extracted and the cavity packed.

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