Super-disintegrating agents are one of the ingredients used in pharmaceutical solid dosage forms. These substances play a vital role in formulation design.  Natural super-disintegrants have gained more popularity due to their oral bioavailability. It disintegrates the tablets into smaller particles to enhance the dissolution rate. Fast dissolving, chewable tablets, and other orally administered dosage forms consist of super-disintegrating agents which shows rapid and quick action. Natural super disintegrating agents in pharmaceutical dosage forms are very effective due to their ecofriendly nature as well as these are biocompatible and biodegradable. These are abundantly and cheaply available from nature.Today the researchers are focusing on naturally available excipients. Keywords: Natural Superdisintegrants, Disintegration, Bioavailability, Biocompatible, Biodegradable.

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The objective of research study was to fabricate neomycin sulphate loaded transferosomal vesicles by modified handshaking technique to increase the permeability of drug through vaginal mucosa. Tween80, span80, tween20, span20, Cremophor EL, brij35, sodium deoxycholate were used at three different concentrations by keeping drug concentration remains constant in all formulations. Stable vesicular formulation was obtained with span80 which is a better intercalatable surfactant in phospholipid layer, results also proved that that the fabricated neomycin sulphate loaded transferosomes were stabilized in terms of zetapotential +5mV homogenously dispersed with PDI value of 0.368 and particle size 152.8nm, entrapment efficiency values are 89.87%. Lipid extrusion test also concluded that fabricated neomycin sulphate loaded transferosomes were highly deformable in nature with   deformability index value of 31.8. DSC of freeze dried nanosuspension  results revealed that neomycin sulphate  loaded transferosomes does not contain any peak related to neomycin sulphate  could be due to complete loading of drug into vesicles, X-diffractogram patterns of a freeze dried nanosuspension also revealed that conversion of drug into loose lattice arrangement indicating amorphous nature of drug , in turn  imposing  loading more quantity of drug.

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The drugs mostly present are available with less bioavailability  and the problem arises with less permeation or solubility  so extensive work is done to enhance these mechanisms. Not only that drugs should pass hepatic metabolism, Inorder to improve its bioavailability they are formulated as transferosomes which can improve the patient compliance by delivering the drug through the transdermal-route. Soya lecithin is used as a phospholipid whereas Tween 60, Tween 80, Span 60 and Span 80 are used as edge activators. These formulations usually showed more entrapment efficiency. The reason behind this is due to the presence of more phospholipids and as the surfactant concentration increases drug release will be rapid. As our main aim is to enhance the bioavailability this can be achieved by optimizing the concentrations of phospholipid and surfactant one can attain a controlled release of drug through this drug delivery system.