Applying human biological evolution to solve topical problems of medicine and preventive cardiology was inspired by the realization of the need for clinical and experimental studies of biological (evolutionary) prerequisites in the occurrence of a pathology. Although it has been stated that there is a need to provide a full biological understanding of features, including those that increase an animal’s vulnerability to diseases, unfortunately, in this regard, erectile and associated adaptations to the Earth’s gravity in their physiological and pathological manifestations have not been considered. At the same time, it should be noted that humans, unlike other animal species, have the greatest vulnerability of the cardiovascular system (CVS). The latter is associated with fundamental differences in the functioning and regulation of the CVS by the influence of gravity on blood circulation in humans as upright creatures. Based on a review of comparative physiological, ontogenetic, and clinical studies from an evolutionary perspective, the idea of adaptation to the Earth’s gravity when walking upright in humans is justified as an anthropogenic basis for the physiology and pathology of the cardiovascular system and hemodynamic support systems (physio-anthropology and pathological anthropology).

The aim of the study was to clarify the features of adaptation of the cardiovascular system (by hemodynamic parameters) to the conditions of the earth's gravity in different periods of ontogenesis. Methods: The analysis was conducted for the number of age groups: up to 8 years (n=55), 9-14 years (n=68), 15-21 years (n=226), 22-35 years (n=326), 36-55 years for women and 36-60 years for men (n=658), up to 70 years (n=413) and over 70 years (n=198). The study of the cardiovascular system was carried out on the hardware and software complex "ANTHROPOS-CAVASCREEN" created by us on the basis of tetrapolar thoracic and regional rheography. Three orthostatic types of hemodynamics (hypokinetic, eukinetic and hyperkinetic) are determined by the ratio of minute blood volume standing/lying. Results: The age limit of transition to the increase in the severity of hyperkinetic organization of blood circulation (corresponding to the orthostatic type III of hemodynamics) is the first reproductive age (22-35 years). The age dynamics of the typological structure indicates that the orthostatic type of hemodynamics is a dynamic characteristic of the organization of blood circulation and it must be taken into account when assessing the circulatory state of the cardiovascular system. K E Y w o r d sage , hemodynamics, orthostatic type.

An innovative diagnostic complex has been created that allows a systematic approach to analyzing the performance of various blood circulation sections-the heart itself and its regulation (ECG), central and peripheral hemodynamics (according to the reogramme), skin circulation (up to 382 indicators). This allows for a qualitatively different level to assess the state of healthy individuals and patients in the prone and standing position, and to use these data for the diagnosis and correction of treatment.

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