To the Editor: Whether bupropion is effective in the treatment of panic disorder is still a matter of debate. We report the case of a 47-year-old man with panic disorder initially treated with bupropion 150 mg daily. At 300 mg daily (because of the recurrence of anxiety symptoms) he had only a partial response to treatment, and he developed chest pain, severe agitation, increased anxiety, and cognitive impairment. Although the present data were limited by the nature of this case presentation, we suggest that bupropion may be a useful effective treatment option in patients with panic symptoms at only 150 mg daily.About 1 in 20 people in the U.S. has a lifetime diagnosis of panic disorder. Recently, it was reported that in the U.S., the overall 12-month and lifetime prevalence rates for panic disorder (with or without agoraphobia) were, respectively, 2.1% and 5.1%, whereas the 12-month and lifetime prevalence rates for panic disorder with agoraphobia were, respectively, 0.6% and 1.1%. 1 Panic disorder with or without agoraphobia is more common in women, middle-aged people, people with low income, and in those who were widowed, separated, or divorced. 1 Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are commonly used to treat both depressive and anxiety disorders. 2 Bupropion is the only antidepressant with a combined action on LETTERS