From the ethyl acetate-soluble fraction of the drug Ed/pta a/ba (L.) Hassk. Asteraceae, besides a flavonoid and simple phenolcarboxylic acids, the coumestans wedelolactone and demethylwedelolactone were isolated as the main active principles. Both constituents exhibited antihepatotoxic activity in assays employing CC!4-, GaiN-, and phalloidin-cytotoxicity in rat hepatocytes. They also showed a significant stimulatory effect on liver cell regeneration. A HPLC-method is described for qualitative and quantitative analysis of the coumestans, in the extracts of Eclipta a/ba and also Wedelia ca/endulacea Less., Asteraceae.

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