Indole derivatives are most important lead compounds in drug development due to their wide range of pharmacological activity and more abundance in nature. There are more than 2000 indole derivatives were reported in various classes of heterocyclic groups. Most generally applicable synthetic process for indole moiety involves ring closure literature reported. Dephenyl sulfonation of non-aromatic side chains was reported with sodium amalgam in methanol. But the first time here in this research the authors presented a new method for dephenyl sulfonylation with magnesium turnings and synthesis of targeted molecule 5-ethyl-1H-indole from 5-[2-(phenyl sulfonyl)ethyl]-1H-indole with good yield and purity. Generally substituted indoles prepared by Fischer indoles synthesis [1] or by electrophilic substitution on benzo portion or pyrole portion of indoles or by functional group inter conversion methodology [2]. 5-Alkyl substitution reactions very tuff, when 1 st , 3 rd position is free by Friedal-Craft alkylation or acylation. After revealing the available literature of 5 th position alkyl substitution of indole [3], it is understood that the process for making simple 5-ethyl-1H-indole is nowhere reported, but its 1 st , 3 rd substituted 5-ethyl indoles has reported [4] (C5alkylation by protecting indoles as N-acetyl and the bromide of 1, 3 protected indoles replaced with triethyl borate in presence of palladium(II) acetate). The introduction of acyl substituents onto the 5 th position of protected indolines were reported by Ketcha and Gribble [5] by simple Friedel Craft acylation of N-protected indoles. In the course of synthesizing impurities of eletriptan hydrobromide drug master file deficient. It is tried to procure 5-ethyl-1H-indole (2) as a precursor for synthesis of Impurity-E.

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