A novel topology of Single phase grid connected system based on photo voltaic system through high gain single switch DC-DC Luo converter is proposed in this paper. In this novel topology the single phase grid connected to PV-Wind system followed by Luo converter and single phase voltage source inverter. The PV system voltage fluctuation problems are overcome by maximum power point tracking algorithm. The new optimized Artificial Neural Network technique (ANN) is used. It extracts the maximum power from the PV system. To compare the conventional schemes the proposed topology is modeled with the help of reference frames includes direct axis and quadrature axis elements. The LUO converter inherits the advantages compared to other DC-DC to converter topologies. The ANN based MPPT algorithm shows excellent performance under various testing conditions and the outcomes are differentiated with P&O algorithm and Fuzzy based MPPT algorithm. The PWM generators are used to trigger the inverter and LUO converter. Steady state and transient response of the controllers are discussed and implement the excellent operation of the PV fed energy system. The grid current synchronization is achieved by using PI controller also reduces the THD and satisfies the IEEE harmonics standard. The proposed system reduces the power quality issues in the PV based single phase grid connected system.