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This study evaluates the chemical composition and anti-diabetic properties of fresh and shade driedJatropha curcas aqueous leaves extracts (JCLE) on alloxan induced diabetic female wistar rats. Seven (7) kg of J. curcas leaves were pulverized and aqueous extracts produced. Thirty five (35) mature female rats were grouped into seven of five animals per group according to their body weights. Blood samples were collected for baseline data before inducing diabetes. Various groups of rats were fed graded doses (100, 200 and 300 mg of JCLE, respectively. Blood glucose was tested every seven days using glucometer. The animals were treated for 21 days with JCLE, blood samples were collected for liver enzyme function test, liver and pancreas tissues collected for histopathology. The results obtained were analysed statistically using analysis of variance (ANOVA) and Duncan Multiple range student test. Result shows that proximate composition of JCLE had higher protein, fat and carbohydrate concentrations in shade dried than the fresh samples. The vitamin, mineral and phytochemical compositions varied but higher in shade dried JCLE also than the fresh. Rats treated had significant (p<0.05) reduction in blood glucose level. Liver enzymes was higher with shade dried JCLE. The current study provides some useful insight into the anti-hyperglycemic potency of JCLE in alloxan induced diabetics and seems to repair some organs damages.

Objectives There is a growing public health concern on the indiscriminate use of pesticides in agriculture among farmers from developing countries including Nigeria. The presence of pesticide residues in food samples may pose a deleterious effect on food safety and consequently compromise the health of consumers especially children, elderly, and pregnant women. The estimation of pesticides residues via dietary intake constitutes a vital integral part of regulatory processes that seeks to preserve public health. This study is therefore focused on the estimation of some pesticide residues in samples of Irish potatoes collected from Jos Nigeria. Methods The samples were collected from five different markets in Jos Plateau State Nigeria. All the samples were transported to the Central Research Laboratory, Ilorin, Nigeria. The pesticide residue analysis was carried out using GC/MS after sample extraction, filtration and Concentration. After the analysis was carried out, the result obtained were subjected to statistical analysis using SPSS (Statistical Package for Social Sciences) statistical software (version 21) after which the Mean, Standard deviations and ANOVA (Analysis of variance) were calculated. Results The result shows that 17 different pesticide residues were identified with ten (10) organochlorines, two (2) organophosphates, one (1) thiocarbamate, one (1) benzamide and two (2) of them were unclassified. The concentration of these pesticides were determined which was then used to determine the estimated daily intake. The ADI and MRL for each pesticide was sought for and the health risk was also evaluated. With the results obtained, it was noticed that most of these pesticides usually exceed their ADI and MRL which then makes them hazardous to the human health. Considering the health risk index of consumers Aldrin, Heptachlor, Mecarbem and Dieldrin proved to be very hazardous (P &gt; 1). Conclusions These pesticides can cause harmful effects on the food commodities which ultimately cause a damaging impact on the health of human. To guarantee food safety, continuous monitoring is recommended for pesticide residues in Irish potatoes. Funding Sources Self-sponsored.