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In this paper we prove that Inter-Symbol Interference (ISI) and Bit Error Rate (BER) of a Diffusion Based Molecular Communication (DBMC) system depend on the apriori probability of the transmitted data by deriving lower and upper bounds for the number of received molecules. We also compute the optimal value of a-priori probability for which ISI and BER are minimized. A source coding technique, called Modified Inverse Source Coding (MISC), is proposed that allows to control the a-priori probability of the transmitted data. The results show that the MISC-DBMC system not only provides a better BER performance compared to an uncoded one but also improves the range of communication.Index Terms-Diffusive channel, molecular communication, inverse source coding, inter-symbol interference, bit error rate.

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