To present how advances in science have helped to improve life expectancy in the world today Material and Methods: A comprehensive literature review of the history of the technological advances that have helped improve both the quality and life expectancy of humans was performed Results: The history of mankind is, among other things, the story of how man has struggled to tame nature, to make it a little less natural. For a long time we have clearly lost the battle. From the 10,000 B.C. until the eighteenth-nineteenth century, progress was scarce and life expectancy barely lasted. Since the industrial revolution, gradually, some improvements, artificial course, as the first steps or sewage system was pushed upwards. Many of the trends that advocate a return to nature or recover ancient therapeutic techniques take us back to a nice little existence. The many advances in medicine and other disciplines, such as vaccines, antibiotics, immunosuppressants, etc. have enabled life expectancy in Spain is currently 82.5 years. Before all those artificial, synthetic and industrial progress, only one of every 1,000 live births reached that age. Conclusion: Scientific medicine has refined the findings that have been made throughout history and does not rule out anything that works and improve life; it is natural or artificial complete devoid of importance.-Oral Presentation 50 TITLE: Hyaluronic acid in cosmetic filler of perioral soft tissues. Case report