The subject of research is the enterprise innovative activity. The purpose of the work is the formation of a methodological approach to assess the innovation activity development. The article systematizes the problem of assessing the effectiveness of industrial enterprise innovative activities. As a result of the study, the following tasks are solved: the need to assess the effectiveness of enterprise innovative activities is considered and substantiated; the essence of innovative activities and innovation is disclosed; theoretical provisions that justify the modern methodology for assessing the development of enterprise innovative activities are formulated; main categories are clarified; a general methodology for assessing the enterprise innovative activity is proposed and the main stages of its implementation are formulated; a comprehensive assessment of the industrial enterprise innovative activity is carried out on JSC Concern Constellation in order to determine the level of its development. The proposed methodological approach to assess the development of innovative activities of the organization, based on a comprehensive assessment of the main areas of innovation, allows identifying the most promising areas (types) of innovative activity of the enterprise in accordance with development priorities. The practical significance of the research results lies in the possibility for state authorities to use the methodology to assess the development and forecast the trends of innovative development of enterprises in the region.