RAM sobre a morbimortalidade, tempo de colonização do paciente após alta hospitalar e ônus econômico para o sistema de saúde. ConClusões: Tais achados poderão auxiliar as pastas governamentais a estabelecer prioridades nacionais para vigilância, prevenção, controle e combate à RAM. Muscular-skeletal DisorDers -clinical outcomes studies PMs1Distribución GeoGráfica y acceso a teraPias biolóGicas en Pacientes con DiaGnóstico De artritis reuMatoiDe (ar) en coloMbia

RHU is the oldest endurance sport in Uruguay. However, despite 80 years of racing, there are no studies to characterize this type of competition, explore rates and causes of death, and identify the associated risk factors. The aim was to characterize the Raid Hipico Uruguayo (RHU) competencies according to the distance (short (SR, 60 km) vs. long (LR, 80–115 km)), the causes of deaths, and the associated risk factors. The study population comprised horses (n = 16,856) that participated in RHU rides from 2007 to 2018. LR were more frequent than SR (p < 0.001). The average speed of winners was higher in SR (32.12 km/h) than in LR (28.14 km/h) (p < 0.001). There were 99 fatalities (5.9 per 1000 starts). SR had greater frequency of high comfort index (CI = Temp [°F] + Humidity [%]) than LR, and LR had greater frequency of low CI than SR (p < 0.001). The percentage of inexperienced horses and those who completed the ride was greater in SR than in LR (p < 0.001). In both types of rides, more horses died during than after the ride, and inexperienced horses were more likely to suffer fatalities than horses with prior experience in the sport (p < 0.05). SR were associated with increased risk of sudden death, while LR were associated with increased risk of death due to metabolic alterations. The high fatality index shown in this work warrants urgent investigation in this sport to minimize mortality associated with RHU-specific diseases.

A837was tolerability related to the number of withdrawals patients in each study, due to the presence of adverse events or treatment failure. The analyses were performed using software Addis (v.1.16.5) and RevMan (5.1). Results: A total of 979 documents were initially identified and 11 of them met the selection criteria to meta-analysis. No significant differences were observed between the number of withdrawals patients due adverse events in any meta-analysis of control versus intervention. The odds ratio ranged from 0.68 (CI 032-1.45) to placebo versus asenapine, 1.37 (CI 0.29-1.33) to placebo versus iloperidone and 0,71 (CI 0,36-1,41) to placebo versus lurasidone. However, all drugs were superior to their respective controls for the outcome of number of withdrawals by treatment failure, with odds ratio between 1.70 (CI 1.21-2.39) and 2.36 (CI 1.36-4.07). These results suggest that there is a higher effectiveness among patients for the treatment intervention that should be evaluated through clinical responses. Heterogeneity between studies (evaluated by I2 values) were low or moderate, not superior than 39,5% in any meta-analysis. ConClusions: Information and knowledge reunion and confrontation on the tolerability profile of a particular drug allows safer decisions over the therapeutic approach, focused on patient's interest which directly reflects on treatment follow-through and therapy effectiveness. In this study, we report evidence on asenapine, iloperidone and lurasidone greater tolerability profile compared to placebo in schizophrenia treatment.

do usuário, um processo que reconhece o direito de participação nas decisões que afetam o cotidiano e promove espaços democráticos para o controle social das instituições, representa forma de participação popular mais contemporânea, inclusive consoante com a ideologia da LAI. Esse movimento ativo da sociedade, demandar o sistema, provoca a percepção por unidades gestoras da importância do envolvimento do usuário. Para essa interlocução é necessário adaptar a linguagem para que se disseminem informações compreensíveis e, de fato, úteis à sociedade. Com isso, a área de avaliação de tecnologias em saúde do Ministério da Saúde teve que se mobilizar para fornecer informações direcionadas aos usuários, fortalecendo seu papel de informá-los a respeito do valor relativo das tecnologias com informações confiáveis, sólidas e transparentes, inclusive seus impactos ético e social. Nesse contexto, a LAI, como instrumento oportuno de participação social, é uma ferramenta capaz de direcionar as demandas e ações de saúde, conferindo maior transparência ao processo.

the new antipsychotic users. The outcome was time to first foster care placement transition during a 180-day follow-up. Cox proportional hazard models estimated hazard ratios (HRs) associated with antipsychotic initiation, adjusting for demographic, clinical, and foster care characteristics. RESULTS: Comparing new users to propensity-score matched nonusers, there was no difference regarding average days to placement transition (109 versus 113 days). The proportion experiencing a foster care placement transition (37% versus 36%) during the follow-up. The HR was 1.1 (95% CI: 0.7-1.6). CONCLUSIONS: Youth initiating antipsychotics had no significant reduction in foster placement transitions within the 180-day follow-up. Although antipsychotics are widely used for aggressive behaviors, a better understanding of clinical management of youth in foster care is needed to promote stable foster placement. PMH64Utilization Pattern of antiPsycHotic DrUgs in a soUtH inDian tertiary care HosPital