The aim is to study the level of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-2 (IGF-2) in the blood serum of patients with papillary thyroid cancer, depending on the main clinical and morphological features of the disease. Materials and methods: The material was the information about 60 patients with papillary thyroid cancer (group 1). In group 2 there were 10 patients without oncopathology. All patients underwent clinical examination after total thyroidectomy before special treatment (radioiodine therapy): ultrasound diagnosis of the neck, confirmed diagnosis of papillary thyroid cancer by morphological examination of operative material. All patients underwent anthropometric studies (height, weight), on the basis of which the body mass index (BMI) was calculated. The study program also included determination of the level of thyroid-stimulating hormone of the pituitary gland (TSH), thyroglobulin (TG), antibodies to thyroglobulin (AB-TG). It was also determined the serum glucose level. In order to assess insulin resistance, the HOMA-IR index was calculated. All patients were tested for serum IGF-1 and IGF-2. Results: In the blood serum of patients with papillary thyroid cancer in 63% of patients the level of IGF-1 and in 85% – IGF-2 was probably higher than in the control group. There is a relationship between the level of IGF-1, IGF-2 and elevated level of proliferating factor – insulin in the serum of patients with papillary thyroid cancer. This may indicate an aggressive potential of the disease (i.e. clinical data on the prevalence of papillary thyroid cancer coincide with laboratory data). There was found a relationship between the expression of IGF-1, IGF-2 and insulin: at elevated levels of insulin> 24.9 μIU/ml, IGF-1 increases 4.2 times, and IGF-2 – 2.5 times. Evaluation of the relationship between the level of IGF-1 and IGF-2 and cervical lymph node involvement shows that in the absence of lesion (N0) there is an increase in these indicators by 2.2 and 1.8 times, respectively. Conclusions: The signaling system of insulin-like growth factors (IGF-1 and IGF-2) plays an important role in the occurrence and progression of malignant tumors. It is especially true for papillary thyroid cancer, so its components can be considered as potential diagnostic and prognostic markers of the disease and targets for anticancer therapy.

Metastasis of malignant tumors are one of the most acute problems of oncology. Among the organs and systems of the human body in terms of frequency of damage, one of the first places is occupied by the lungs, which is probably closely related to the anatomical features of their structure and physiology. During the first examination of cancer patients, metastases in the lungs are revealed in 6-15%, lymphogenous metastases are observed in 50-81%. With differentiated thyroid carcinoma (thyroid gland), metastases in the lung are most often detected (up to 15% of cases). At the same time, 5- and 10-year survival rates are 50-92.6% and 42-86%, respectively. The use of 131I-sodium iodide is central to the treatment of these patients. The purpose of the paper is to study the effectiveness of radioiodine therapy for metastases of thyroid carcinoma in the lung. We used clinical, laboratory, radiological methods for the diagnosis of thyroid carcinoma and pulmonary metastases. From 1986 to 2010, 68 patients from the clinic of the S.P. Hryhoriev Institute of Medical Radiology of the Academy of Medical Sciences of Ukraine were included in the study. Lung metastases were found in patients with all stages of the disease and with diverse sizes of the primary thyroid tumor. After the surgical treatment of patients, 131Isodium iodide was used in various doses of radioactivity. The full therapeutic effect of radiotherapy was achieved in 5 patients (7.8%) over a 3-year period of treatment, and a 5-year period – in 28 (43.8%); stabilization or partial effect was noted in 24 patients (37.8%), disease progression was observed in 12 patients (17.6%). Mortality from disease progression was 12.5%.

Using infrared spectroscopy, we studied the character of intermolecular interactions in the samples blood plasma of oncological patients with bone metastases in the treatment of their modern β-emitter 153Sm-oxabifor. The therapeutic dose of the 153Sm-oxabifor was 1.0 mCi/kg of the patient's body weight. Analysis of the IR-spectra showed that already after the first course of palliative radionuclide therapy there is a tendency to balance the products of free radical nature and antioxidants, which indicates the effectiveness of the treatment. Molecular changes in the blood plasma of cancer patients with bone metastases registered using infrared spectroscopy are specifc during palliative therapy.

Background. Higher education internationalization is a process develop­ing at national, industry-specific and institutional levels, when the goals, functions and mechanism of providing educational services become inter­national in nature. A distinctive feature of modern university education is a high rate of in­ternationalization and global introduction of teaching medical disciplines in English. International cooperation has been and remains one of the pri­orities of KNMU development. It is an integral part of the university life developing within the framework of the higher school of Ukraine in higher education world system. Purpouse of the paper is to analyze higher medical education internation­alization development due to English medium at KNMU, new directions of improving teaching radiology and radiation medicine using modern in­novative technologies. Material and methods. International work experience and pedagogi­cal and professional internships; experience of training foreign students of the authors as well as the teachers of others departments. The litera­ture sources and and information provided at KNMU official website have been used and analyzed. Results. The necessary components of internationalization of teaching in English medium is a high level of English proficiency of university teaching personnel; sufficient material and technical resources; continuous training of teachers following and taking into account international teach­ing experience, participation in international educational conferences. Conclusions. Higher education internationalization is an inevitable pro­cess developing at national, industry-specific and institutional levels; it implies that the goals, functions and mechanism of providing educa­tional services become international and have a high rate of international­ization and global implementation of teaching medical disciplines in Eng­lish medium.

He most important trends in reforming national education systems in most developed countries are the internationalization of the education system and the integration of the educational space. Both Ukraine and Kharkov National Medical University joined this process. Therefore, at present, the task has arisen of creating unified educational programs for the training of masters in specialty 224 «Technologies for medical diagnostics and treatment» specializing in laboratory diagnostics. Such a curriculum was the silabus created by the Department of Radiology and Radiation Medicine of KNMU, that is, information about the subject of study of a discipline, a description of interdisciplinary connections, goals and objectives of a discipline, competence (integral, general and special) and learning outcomes, a thematic plan, description independent work of students, the definition of knowledge control methods, a description of the assessment of the discipline, a list of educational literature or online sources for preparing students. Unlike the traditional curriculum, the force bus includes exactly three types of competencies, which allow the student to gain experience in successful contact with other students, teachers, in the future — with colleagues and work experience in a «team». In addition to special knowledge and skills, a student at the end of higher education becomes an educated member of a social society, can fulfill not only his professional or professional duty, but also has a certain civic position. In addition, the modern system of higher education involves continuing education throughout the professional life