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Transfer of radioactive particles in the environment is an important issue important for both radiobiology and radioecology. The article presents an analysis of the main patterns of “hot” radioactive particles transport in the digestive tract of monogastric animals (rats, guinea pigs and pigs), which serve as reference organisms in the tasks of assessing the radiation risk of environmental contamination. The models of particle transport in the gastrointestinal tract of monogastric animals were developed and their parameters were estimated.