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RESULTS: The mean age of patients was 68.8 years (range: 56-90). All patients had BPH except for one who had low grade adenocarcinoma (not considered in PSAt evaluation). At the beginning of the treatment 3 patients had indwelling catheters.CONCLUSIONS: We consider intraprostatic BTX-A injection as a mutually exclusive alternative to surgery in high grade voiding dysfunction, for BPH or cancer, particularly in patients at risk. BASELINE1 MONTH 2MONTHS &MONTHS p IPSS 24 13 11 9 0.002 Prostate weight gr. 106 65 53 53 0.000 PSAtng/ml.