We describe the major autopsy findings in two adult sibs of the original pedigree of Lowry et a1 [Am J Dis Child 12 1 :496-500, 197 11. These results support the idea that Coffin-Lowry syndrome is a systemic connective tissue disorder. Visceral neuropathy was also noted as the basis of extensive intestinal diverticular disease.

We describe a fetus with an asymmetric, nonmidline, parietal encephalocele that appeared to result from "expulsion" through the center of the membranous bone; the fetus also had laryngeal atresia, which caused pulmonary overdistension (fetal Valsalva maneuver) with consequent hydrops fetalis. A common cause and clear pathogenetic relationship between these anomalies is not apparent.

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During forensic examination of male fertility in disputed paternity cases cheating is possible. There are substances with effects on spermatogenesis; on transport of spermatozoa and on hormonic regulation. Bis-dichloroacetyl-octamethylendiamine seems the most suitable. It has no side-effects, exept for an antabuse-effect. By daily treatment with 200 mg sterility starts after 2--3 months. After stopping the treatment fertility becomes normal after 2 months.

A 60-year-old woman received a 3-day course of nine injections of "fresh" cells from fetal lamb ovary, placenta, brain (hypothalamus) and liver. There were no immediate complications, but a few days later she developed headache, fever and hemiparesis. She subsequently fell into a coma and died 3 weeks after her fresh cell therapy and 2 weeks after the onset of her clinical symptoms. Autopsy revealed perivenous leucoencephalopathy with a probably steroid-treatment-induced paucity of perivascular inflammation. Fresh cell therapy, clinical symptomatology and morphological findings suggest, though do not prove, that this patient's monophasic and probably immune-mediated disease is a rare fatal complication of fresh cell therapy.